Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation

Severe psoriasis, a chronic inflammatory skin disease is increasingly being effectively managed by targeted immunotherapy but long-term poses health risk and loss of response. Therefore, there need for alternative therapy strategies. Mesenchymal stem/stromal cell (MSC) exosomes are widely known their potent immunomodulatory properties. Here we investigated if topically applied MSC could alleviate psoriasis-associated inflammation. Topically fluorescent on human explants were confined primarily to the stratum corneum with <1% input fluorescence exiting explant over 24-h period. Nevertheless, in mouse model imiquimod (IMQ) psoriasis significantly reduced IL-17 terminal complement activation complex C5b-9 skin. previously shown inhibit activation, specifically formation through CD59. Infiltration neutrophils into characteristic major cellular source release neutrophil extracellular traps (NETs). We propose that this alleviates NETS from accumulate beneath corneum.